| QB | QB10Season rank QB10 through week 1, inside the league's starting line: Joe Burrow 10.82 | QB4Season rank QB4 through week 1, inside the league's starting line: Patrick Mahomes 28.02 |
| RB | RB7Season rank RB7 through week 1, inside the league's starting line: Saquon Barkley 16.40 | RB19Season rank RB19 through week 1, inside the league's starting line: Bucky Irving 12.50 |
| RB | RB15Season rank RB15 through week 1, inside the league's starting line: Kyren Williams 13.40 | RB20Season rank RB20 through week 1, inside the league's starting line: James Conner 12.40 |
| WR | WR4Season rank WR4 through week 1, inside the league's starting line: Deebo Samuel Sr. 19.10 | WR16Season rank WR16 through week 1, inside the league's starting line: Justin Jefferson 12.80 |
| WR | WR52Season rank WR52 through week 1, outside the league's starting line: Cooper Kupp 2.50 | WR23Season rank WR23 through week 1, inside the league's starting line: Drake London 9.50 |
| WR | WR50Season rank WR50 through week 1, startable in a flex slot: Jauan Jennings 2.60 | WR60Season rank WR60 through week 1, outside the league's starting line: Xavier Worthy 0.00 |
| TE | TE7Season rank TE7 through week 1, inside the league's starting line: Trey McBride 9.10 | TE10Season rank TE10 through week 1, inside the league's starting line: Evan Engram 3.60 |
| FLEX | RB9Season rank RB9 through week 1, inside the league's starting line: Breece Hall 15.50 | WR36Season rank WR36 through week 1, startable in a flex slot: Rashid Shaheed 6.30 |
| FLEX | RB35Season rank RB35 through week 1, startable in a flex slot: David Montgomery 6.30 | WR49Season rank WR49 through week 1, startable in a flex slot: Matthew Golden 2.60 |
| K | K4Season rank K4 through week 1, inside the league's starting line: Harrison Butker 10.00 | K2Season rank K2 through week 1, inside the league's starting line: Tyler Loop 12.00 |
| DEF | DEF1Season rank DEF1 through week 1, No. 1 at the position: DEN Defense 16.00 | DEF8Season rank DEF8 through week 1, inside the league's starting line: BUF Defense 2.00 |