| QB | QB7Season rank QB7 through week 10, inside the league's starting line: Baker Mayfield 28.92 | QB6Season rank QB6 through week 10, inside the league's starting line: Jared Goff 30.80 |
| RB | RB10Season rank RB10 through week 10, inside the league's starting line: Saquon Barkley 11.60 | RB7Season rank RB7 through week 10, inside the league's starting line: James Cook III 8.20 |
| RB | RB3Season rank RB3 through week 10, inside the league's starting line: De'Von Achane 37.50 | RB6Season rank RB6 through week 10, inside the league's starting line: Bijan Robinson 9.80 |
| WR | WR24Season rank WR24 through week 10, inside the league's starting line: Zay Flowers 10.10 | WR42Season rank WR42 through week 10, startable in a flex slot: Jerry Jeudy 16.80 |
| WR | WR31Season rank WR31 through week 10, startable in a flex slot: Quentin Johnston 6.70 | WR12Season rank WR12 through week 10, inside the league's starting line: Ladd McConkey 18.70 |
| WR | WR33Season rank WR33 through week 10, startable in a flex slot: Wan'Dale Robinson 9.20 | WR40Season rank WR40 through week 10, startable in a flex slot: Jakobi Meyers 5.60 |
| TE | TE7Season rank TE7 through week 10, inside the league's starting line: Brock Bowers 3.20 | TE5Season rank TE5 through week 10, inside the league's starting line: Sam LaPorta 7.80 |
| FLEX | RB23Season rank RB23 through week 10, startable in a flex slot: Kenneth Walker III 7.50 | RB17Season rank RB17 through week 10, inside the league's starting line: J.K. Dobbins 8.90 |
| FLEX | WR52Season rank WR52 through week 10, outside the league's starting line: Alec Pierce 16.40 | TE14Season rank TE14 through week 10, startable in a flex slot: Hunter Henry 1.40 |
| K | K5Season rank K5 through week 10, inside the league's starting line: Tyler Loop 13.00 | K1Season rank K1 through week 10, No. 1 at the position: Cameron Dicker 13.00 |
| DEF | DEF5Season rank DEF5 through week 10, inside the league's starting line: BUF Defense 3.00 | DEF2Season rank DEF2 through week 10, inside the league's starting line: PHI Defense 13.00 |