| QB | QB2Season rank QB2 through week 10, inside the league's starting line: Josh Allen 23.34 | QB9Season rank QB9 through week 10, inside the league's starting line: Daniel Jones 17.50 |
| RB | RB24Season rank RB24 through week 10, startable in a flex slot: TreVeyon Henderson 27.50 | RB5Season rank RB5 through week 10, inside the league's starting line: Josh Jacobs 17.20 |
| RB | RB45Season rank RB45 through week 10, outside the league's starting line: Kyle Monangai 8.80 | RB13Season rank RB13 through week 10, inside the league's starting line: Rico Dowdle 13.80 |
| WR | WR2Season rank WR2 through week 10, inside the league's starting line: Amon-Ra St. Brown 14.30 | WR10Season rank WR10 through week 10, inside the league's starting line: Jaylen Waddle 16.90 |
| WR | WR16Season rank WR16 through week 10, inside the league's starting line: Courtland Sutton 3.90 | WR26Season rank WR26 through week 10, inside the league's starting line: Romeo Doubs 1.00 |
| WR | WR37Season rank WR37 through week 10, startable in a flex slot: Jordan Addison 5.00 | WR27Season rank WR27 through week 10, inside the league's starting line: Khalil Shakir 9.30 |
| TE | TE10Season rank TE10 through week 10, inside the league's starting line: Dalton Kincaid 4.70 | TE20Season rank TE20 through week 10, startable in a flex slot: Cade Otton 12.70 |
| FLEX | TE17Season rank TE17 through week 10, startable in a flex slot: Oronde Gadsden 2.80 | WR61Season rank WR61 through week 10, outside the league's starting line: Troy Franklin 12.50 |
| FLEX | RB22Season rank RB22 through week 10, startable in a flex slot: Jaylen Warren 10.10 | RB19Season rank RB19 through week 10, inside the league's starting line: David Montgomery 9.60 |
| K | K18Season rank K18 through week 10, outside the league's starting line: Will Reichard 9.00 | K9Season rank K9 through week 10, inside the league's starting line: Eddy Pineiro 1.00 |
| DEF | DEF6Season rank DEF6 through week 10, inside the league's starting line: SEA Defense 23.00 | DEF9Season rank DEF9 through week 10, inside the league's starting line: DET Defense 2.00 |