| QB | QB17Season rank QB17 through week 6, outside the league's starting line: Drake Maye 29.80 | QB4Season rank QB4 through week 6, inside the league's starting line: Brock Purdy 19.36 |
| RB | RB35Season rank RB35 through week 6, startable in a flex slot: Braelon Allen 11.40 | RB4Season rank RB4 through week 6, inside the league's starting line: Derrick Henry 4.50 |
| RB | RB10Season rank RB10 through week 6, inside the league's starting line: D'Andre Swift 21.00 | RB5Season rank RB5 through week 6, inside the league's starting line: Jonathan Taylor 20.10 |
| WR | WR45Season rank WR45 through week 6, startable in a flex slot: Romeo Doubs 10.70 | WR10Season rank WR10 through week 6, inside the league's starting line: Zay Flowers 9.70 |
| WR | WR40Season rank WR40 through week 6, startable in a flex slot: Khalil Shakir 11.40 | WR31Season rank WR31 through week 6, startable in a flex slot: Denzel Boston 2.00 |
| WR | WR20Season rank WR20 through week 6, inside the league's starting line: Luther Burden III 13.50 | WR21Season rank WR21 through week 6, inside the league's starting line: Stefon Diggs 13.40 |
| TE | TE3Season rank TE3 through week 6, inside the league's starting line: George Kittle 15.40 | TE17Season rank TE17 through week 6, startable in a flex slot: Brenton Strange 6.90 |
| FLEX | RB9Season rank RB9 through week 6, inside the league's starting line: Javonte Williams 12.00 | RB25Season rank RB25 through week 6, startable in a flex slot: Woody Marks 9.10 |
| FLEX | TE24Season rank TE24 through week 6, startable in a flex slot: Tyler Higbee 2.20 | RB13Season rank RB13 through week 6, inside the league's starting line: Ashton Jeanty 13.80 |
| K | K7Season rank K7 through week 6, inside the league's starting line: Brandon Aubrey 1.00 | K1Season rank K1 through week 6, No. 1 at the position: Ka'imi Fairbairn 11.00 |
| DEF | DEF19Season rank DEF19 through week 6, outside the league's starting line: CAR Defense 4.00 | DEF20Season rank DEF20 through week 6, outside the league's starting line: IND Defense 2.00 |